Nisin

Nisin is a naturally occurring bacteriocin produced by Streptococcus lactis that has been used as a food preservative for over 50 years. It is a small peptide with antimicrobial activity that is effective against a wide range of Gram-positive bacteria, including Listeria, Staphylococcus, and Bacillus species. Nisin has been approved for use in more than 50 countries worldwide and is Generally Recognized as Safe (GRAS) in the United States.

The mode of action of nisin is unique and involves binding to the cell wall of sensitive bacteria, causing pore formation and cell death. This process is known as bactericidal activity. Nisin has also been shown to exhibit synergistic effects when used in combination with other antimicrobials, which can enhance its efficacy against resistant bacteria.